Pigmentation Disorders: Molecular Pathways & Novel Treatments
Pigmentation disorders including melasma, vitiligo, hyperpigmentation, and post-inflammatory pigmentation—are influenced by complex molecular pathways involving melanocyte activity, oxidative stress, hormone response, and genetic predisposition. Understanding these mechanisms allows development of more effective therapeutic strategies. Novel agents such as tyrosinase inhibitors, synthetic peptides, antioxidants, and pathway-specific modulators help regulate melanin production with precision. Advanced lasers, chemical peels, and combination treatments further enhance outcomes by targeting pigment at multiple levels of the skin. Research into melanocyte-keratinocyte communication, photobiology, and inflammatory triggers continues to refine intervention protocols. By integrating molecular science with clinical expertise, dermatologists can achieve more stable and longer-lasting pigment correction with reduced risk of recurrence.
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